Обзорная статья

Advances in redox-responsive drug delivery systems of tumor microenvironment

Xiaoshuang GuoEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan RD, Shanghai, 200240, ChinaYuan ChengEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan RD, Shanghai, 200240, ChinaXiaotian ZhaoEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan RD, Shanghai, 200240, ChinaYanli LuoDepartment of Pathology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of ChinaJianjun ChenSchool of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China. [email protected]Weien YuanEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan RD, Shanghai, 200240, China. [email protected]

2018en

ABI

Аннотация

With the improvement of nanotechnology and nanomaterials, redox-responsive delivery systems have been studied extensively in some critical areas, especially in the field of biomedicine. The system constructed by redox-responsive delivery can be much stable when in circulation. In addition, redox-responsive vectors can respond to the high intracellular level of glutathione and release the loaded cargoes rapidly, only if they reach the site of tumor tissue or targeted cells. Moreover, redox-responsive delivery systems are often applied to significantly improve drug concentrations in targeted cells, increase the therapeutic efficiency and reduce side effects or toxicity of primary drugs. In this review, we focused on the structures and types of current redox-responsive delivery systems and provided a comprehensive overview of relevant researches, in which the disulfide bond containing delivery systems are of the utmost discussion.

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Идентификаторы

DOI: 10.1186/s12951-018-0398-2

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar