Статья

RETRACTED ARTICLE: Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2

Lili CaoDepartment of Oncology, Zibo Central Hospital, Zibo, 255020, ChinaMin WangDepartment of Oncology, Zibo Central Hospital, Zibo, 255020, ChinaYujin DongDepartment of Oncology, Zibo Central Hospital, Zibo, 255020, ChinaBo XuDepartment of Oncology, Zibo Central Hospital, Zibo, 255020, ChinaJu ChenDepartment of Ultrasound, Zibo Central Hospital, Zibo, 255020, ChinaYu‐Qiang DingDepartment of Breast and Thyroid Surgery, Zibo Key laboratory of Breast cancer Individualized diagnosis, treatment and transformation, Zibo Central Hospital, Zibo, 255020, ChinaShusheng QiuDepartment of Breast and Thyroid Surgery, Zibo Key laboratory of Breast cancer Individualized diagnosis, treatment and transformation, Zibo Central Hospital, Zibo, 255020, ChinaLiang LiDepartment of Breast and Thyroid Surgery, Zibo Key laboratory of Breast cancer Individualized diagnosis, treatment and transformation, Zibo Central Hospital, Zibo, 255020, ChinaElena Karamfilova ZaharievaDepartment of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, 734-8553, JapanXinwen ZhouSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, 215123, ChinaYanbin XuDepartment of Breast and Thyroid Surgery, Zibo Key laboratory of Breast cancer Individualized diagnosis, treatment and transformation, Zibo Central Hospital, Zibo, 255020, China. [email protected]

2020en

ABI

Аннотация

Compelling evidence has demonstrated the potential functions of circular RNAs (circRNAs) in breast cancer (BC) tumorigenesis. Nevertheless, the underlying mechanism by which circRNAs regulate BC progression is still unclear. The purpose of present research was to investigate the novel circRNA circRNF20 (hsa_circ_0087784) and its role in BC. CircRNA microarray sequencing revealed that circRNF20 was one of the upregulated transcripts in BC samples. Increased circRNF20 level predicted the poor clinical outcome in BC specimens. Functionally, circRNF20 promoted the proliferation and Warburg effect (aerobic glycolysis) of BC cells. Mechanistically, circRNF20 harbor miR-487a, acting as miRNA sponge, and then miR-487a targeted the 3'-UTR of hypoxia-inducible factor-1α (HIF-1α). Moreover, HIF-1α could bind with the promoter of hexokinase II (HK2) and promoted its transcription. In conclusion, this finding illustrates the vital roles of circRNF20 via the circRNF20/ miR-487a/HIF-1α/HK2 axis in breast cancer progress and Warburg effect, providing an interesting insight for the BC tumorigenesis.

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Идентификаторы

DOI: 10.1038/s41419-020-2336-0

Цитирования и источники

Цитирований: 2Использованных источников: 0

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