Обзорная статья

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Ajaz A. BhatTranslational Medicine, Sidra Medicine, P.O. Box 26999, Doha, QatarSalma YounesDepartment of Biomedical Science, College of Health Sciences, Qatar University, Doha, QatarSyed Shadab RazaLaboratory for Stem Cell & Restorative Neurology, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, IndiaLubna ZarifDepartment of Biomedical Science, College of Health Sciences, Qatar University, Doha, QatarSabah NisarTranslational Medicine, Sidra Medicine, P.O. Box 26999, Doha, QatarIkhlak AhmedTranslational Medicine, Sidra Medicine, P.O. Box 26999, Doha, QatarRashid MirDepartment of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi ArabiaSachin KumarDepartment of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, IndiaSurender K. SharawatDepartment of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, IndiaSheema HashemTranslational Medicine, Sidra Medicine, P.O. Box 26999, Doha, QatarImadeldin ElfakiDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi ArabiaMichał KulińskiTranslational Research Institute, Academic Health System, Hamad Medical Corporation, P.O. Box 3050, Doha, QatarShilpa KuttikrishnanTranslational Research Institute, Academic Health System, Hamad Medical Corporation, P.O. Box 3050, Doha, QatarKirti S. PrabhuTranslational Research Institute, Academic Health System, Hamad Medical Corporation, P.O. Box 3050, Doha, QatarAbdul Quaiyoom KhanTranslational Research Institute, Academic Health System, Hamad Medical Corporation, P.O. Box 3050, Doha, QatarSantosh K. YadavTranslational Medicine, Sidra Medicine, P.O. Box 26999, Doha, QatarWael El‐RifaiDepartment of Surgery, University of Miami, Miami, Florida, USAMohammad Afzal ZargarDepartment of Biotechnology, Central University of Kashmir, Ganderbal, Jammu and Kashmir, IndiaHatem ZayedDepartment of Biomedical Science, College of Health Sciences, Qatar University, Doha, QatarMohammad HarisLaboratory Animal Research Center, Qatar University, Doha, Qatar. [email protected]Shahab UddinTranslational Research Institute, Academic Health System, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar. [email protected]

2020en

ABI

Аннотация

Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate.Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.

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Идентификаторы

DOI: 10.1186/s12943-020-01175-9

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar