Обзорная статья

ILAE Official Report: A practical clinical definition of epilepsy

Robert S. FisherDepartment of Neurology & Neurological Sciences Stanford University School of Medicine Stanford California U.S.ACarlos Alberto AcevedoAlexis ArzimanoglouEpilepsy, Sleep and Pediatric Neurophysiology Department University Hospitals of Lyon (HCL) and Lyon Neuroscience Research Center (CRNL) Lyon FranceAlicia BogaczNeurological Institute of Clinical Hospital Universidad Mayor de la República Montevideo UruguayJ. Helen CrossUCL‐Institute of Child Health Great Ormond Street Hospital for Children, London & Young Epilepsy Lingfield United KingdomChristian E. ElgerDepartment of Epileptology University of Bonn Medical Centre Bonn GermanyJerome EngelLars ForsgrenDepartment of Pharmacology and Clinical Neuroscience/Neurology Umeå University Umeå SwedenJacqueline A. FrenchDepartment of Neurology NYU School of Medicine New York New York U.S.AMike GlynnCEO Epilepsy Ireland Dublin IrelandDale C. HesdorfferGH Sergievsky Center and Department of Epidemiology Columbia University New York New York U.S.AB. I. LeeYonsei Epilepsy Research Institute Yonsei University College of Medicine Seoul KoreaGary W. MathernDepartments of Neurosurgery and Psychiatry & BioBehavioral Medicine Mattel Children's Hospital David Geffen School of Medicine University of California Los Angeles California U.S.ASolomon L. MoshéSaul R. Korey Department of Neurology Dominick P. Purpura Department of Neuroscience and Department of Pediatrics Laboratory of Developmental Epilepsy Montefiore/Einstein Epilepsy Management Center Albert Einstein College of Medicine and Montefiore Medical Center Bronx New York U.S.AEmilio PeruccaDepartment of Internal Medicine and Therapeutics University of Pavia and C. Mondino National Neurological Institute Pavia ItalyIngrid E. SchefferDepartments of Medicine and Paediatrics Florey Institute Austin Health and Royal Children's Hospital The University of Melbourne Melbourne Victoria AustraliaTorbjörn TomsonDepartment of Clinical Neuroscience Karolinska Institutet Stockholm SwedenMasako WatanabeDepartment of Psychiatry National Center of Neurology and Psychiatry Tokyo JapanSamuel WiebeUniversity of Calgary Calgary Alberta Canada

2014en

ABI

Аннотация

Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usually practically applied as having two unprovoked seizures >24 h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a task force altering the practical definition for special circumstances that do not meet the two unprovoked seizures criteria. The task force proposed that epilepsy be considered to be a disease of the brain defined by any of the following conditions: (1) At least two unprovoked (or reflex) seizures occurring >24 h apart; (2) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; (3) diagnosis of an epilepsy syndrome. Epilepsy is considered to be resolved for individuals who either had an age-dependent epilepsy syndrome but are now past the applicable age or who have remained seizure-free for the last 10 years and off antiseizure medicines for at least the last 5 years. "Resolved" is not necessarily identical to the conventional view of "remission or "cure." Different practical definitions may be formed and used for various specific purposes. This revised definition of epilepsy brings the term in concordance with common use. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.

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Идентификаторы

DOI: 10.1111/epi.12550

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