Статья

The Investigation of Nfκb Inhibitors to Block Cell Proliferation in OSCC Cells Lines

Yuxi ChengHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center ofOral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & AcademicianWorkstation for Oral-maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & XiangyaSchool of Stomatology, Central South University, Xiangya Road, Changsha, 410011, ChinaLiping WangHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center ofOral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & AcademicianWorkstation for Oral-maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & XiangyaSchool of Stomatology, Central South University, Xiangya Road, Changsha, 410011, ChinaShuju ZhangHunanChildren's Hospital, Changsha, 410011, ChinaJian WeiDental Department, Yueyang Central Hospital, 39# DongmaolingRoad, Yueyang, 414000, ChinaBin ZengDepartment of Stomatology, Changsha Medical University, Changsha,Hunan, 410219, ChinaLong LiangHunan Province Key Laboratory of Basic and Applied Hematology, School ofLife Sciences , Molecular Biology Research Center, 110# Xiangya Road, Changsha, 410011, ChinaZhiyuan DengHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center ofOral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & AcademicianWorkstation for Oral-maxilofacial and Regenerative Medicine & Xiangya Stomatological Hospital & XiangyaSchool of Stomatology, Central South University, Xiangya Road, Changsha, 410011, China

2024en

ABI

Аннотация

BACKGROUND: Oral cancers, with oral squamous cell carcinoma (OSCC) as the predominant type, have a significant impact on morbidity and mortality rates. Therefore, targeting the NFκB pathway shows promise in cancer therapy. MATERIALS AND METHODS: This study investigated the impact of two NFκB inhibitors, LY2409881 and MLN4924, on cell proliferation, apoptosis susceptibility, and in vivo tumorigenesis in OSCC cell lines CAL27 and SCC15. RESULTS: The results revealed that both LY2409881 and MLN4924 effectively suppressed cell proliferation, induced apoptosis, and arrested the cell cycle at the G2/M phase-a phenomenon likely associated with the NFκB pathway. Furthermore, MLN4924 demonstrated potent inhibitory effects on cell proliferation at low μM concentrations, surpassing the effectiveness of LY2409881 as an inhibitor (All results: p<0.05). CONCLUSION: These findings highlight the potential of LY2409881 and MLN4924 as novel therapeutic agents for OSCC, thereby offering new insights for the clinical management of this condition.

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Идентификаторы

DOI: 10.2174/0109298673309489240816063313

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar