Обзорная статья

A Comprehensive Review of mRNA Vaccines

Vrinda GoteDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri, 2464 Charlotte Street, Kansas City, MO 64108, USAPradeep Kumar BollaDepartment of Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W University Ave, El Paso, TX 79968, USANagavendra KommineniCenter for Biomedical Research, Population Council, New York, NY 10065, USAArun ButreddyDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USAPavan Kumar NukalaCollege of Pharmacy and Health Sciences, St. John’s University, 8000 Utopia Pkwy, Queens, NY 11439, USASushesh Srivatsa PalakurthiDepartment of Pharmaceutical Sciences, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX 78363, USAWahid KhanNatco Research Centre, NATCO Pharma Limited, Hyderabad 500018, India

2023en

ABI

Аннотация

mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity to emerging as COVID-19 pandemic vaccine front-runners. The advancements in the field of nanotechnology for developing delivery vehicles for mRNA vaccines are highly significant. In this review we have summarized each and every aspect of the mRNA vaccine. The article describes the mRNA structure, its pharmacological function of immunity induction, lipid nanoparticles (LNPs), and the upstream, downstream, and formulation process of mRNA vaccine manufacturing. Additionally, mRNA vaccines in clinical trials are also described. A deep dive into the future perspectives of mRNA vaccines, such as its freeze-drying, delivery systems, and LNPs targeting antigen-presenting cells and dendritic cells, are also summarized.

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Идентификаторы

DOI: 10.3390/ijms24032700

Цитирования и источники

Цитирований: 2Использованных источников: 0

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