Structure elucidation of new oleanane‐type glycosides from three species of <i>Acanthophyllum</i>
Gaoussou TimitéLaboratoire de Pharmacognosie, UMIB, UPRES EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 bd. Jeanne D' Arc, BP 87900, 21079 Dijon Cedex, FranceAnne‐Claire Mitaine‐OfferLaboratoire de Pharmacognosie, UMIB, UPRES EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 bd. Jeanne D' Arc, BP 87900, 21079 Dijon Cedex, FranceTomofumi MiyamotoGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, JapanMohammad RamezaniDepartment of Pharmacognosy and Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775 1365 Mashhad, IranAbdolhossein RustaiyanDepartment of Chemistry, Shahid Beheshty University, Eveen, Tehran, IranJean‐François MirjoletOlivier DuchampMarie‐Aleth Lacaille‐DuboisLaboratoire de Pharmacognosie, UMIB, UPRES EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 bd. Jeanne D' Arc, BP 87900, 21079 Dijon Cedex, France
2010en
ABI
Аннотация
From the roots of three species of Acanthophyllum (Caryophyllaceae), two new gypsogenic acid glycosides, 1 and 2, were isolated, 1 from A. sordidum and A. lilacinum, 2 from A. elatius and A. lilacinum, together with three known saponins, glandulosides B and C, and SAPO50. The structures of 1 and 2 were established mainly by 2D NMR techniques as 23-O-beta-D-galactopyranosylgypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (1) and gypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (2). The cytotoxicity of several of these saponins was evaluated against two human colon cancer cell lines (HT-29 and HCT 116).
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