Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus
Federico CocozzaINSERM U932 Institut Curie Centre de Recherche PSL Research University Paris FranceNathalie NévoINSERM U932 Institut Curie Centre de Recherche PSL Research University Paris FranceEster PiovesanaINSERM U932 Institut Curie Centre de Recherche PSL Research University Paris FranceXavier LahayeINSERM U932 Institut Curie Centre de Recherche PSL Research University Paris FranceJulian BuchrieserVirus and Immunity Unit Institut Pasteur and CNRS UMR 3569 Paris FranceOlivier SchwartzVirus and Immunity Unit Institut Pasteur and CNRS UMR 3569 Paris FranceNicolas ManelINSERM U932 Institut Curie Centre de Recherche PSL Research University Paris FranceMercedes TkachINSERM U932 Institut Curie Centre de Recherche PSL Research University Paris FranceClotilde ThéryINSERM U932 Institut Curie Centre de Recherche PSL Research University Paris FranceLorena Martín‐JaularINSERM U932 Institut Curie Centre de Recherche PSL Research University Paris France
2020en
ABI
Аннотация
SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2-EVs are efficient decoys for SARS-CoV-2 S protein-containing lentivirus. Reduction of infectivity positively correlates with the level of ACE2, is much more efficient than with soluble ACE2 and further enhanced by the inclusion of TMPRSS2.
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