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Characteristics of ischaemic stroke associated with COVID-19

Rahma BeyroutiComprehensive Stroke Service, University College London Hospitals NHS Foundation Trust, London, London, UKMatthew AdamsLysholm Department of Neuroradiology, University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery, London, London, UKLaura BenjaminBrain Infections Group, Institute of Infection and Global Health, University of Liverpool, Liverpool, UKHannah CohenHemostasis Research Unit, Department of Hematology, University College London, London, UKSimon F. FarmerDepartment of Neurology, University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery, London, London, UKYee Yen GohDepartment of Neurology, University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery, London, London, UKFiona HumphriesComprehensive Stroke Service, University College London Hospitals NHS Foundation Trust, London, London, UKHans Rolf JägerDepartment of Brain Repair and Rehabilitation, University College London Queen Square Institute of Neurology, London, London, UKNicholas LosseffCleveland Clinic, Grosvenor Place, London SW1 X7HY, United KingdomRichard PerryComprehensive Stroke Service, University College London Hospitals NHS Foundation Trust, London, London, UKSachit ShahLysholm Department of Neuroradiology, University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery, London, London, UKRobert SimisterComprehensive Stroke Service, University College London Hospitals NHS Foundation Trust, London, London, UKDavid D. TurnerComprehensive Stroke Service, University College London Hospitals NHS Foundation Trust, London, London, UKArvind ChandrathevaComprehensive Stroke Service, University College London Hospitals NHS Foundation Trust, London, London, UKDavid J. WerringComprehensive Stroke Service, University College London Hospitals NHS Foundation Trust, London, London, UK [email protected]

2020en

ABI

Аннотация

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with coagulopathy causing venous and arterial thrombosis. 1 2 Recent data from the pandemic epicentre in Wuhan, China, reported neurological complications in 36% of 214 patients with COVID-19; acute cerebrovascular disease (mainly ischaemic stroke) was more common among 88 patients with severe COVID-19 than those with nonsevere disease (5.7% vs 0.8%). However, the mechanisms, phenotype and optimal management of ischaemic stroke associated with COVID-19 remain uncertain. We describe the demographic, clinical, radiological and laboratory characteristics of six consecutive patients assessed between 1 st and 16 th April 2020 at the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK, with acute ischaemic stroke and COVID-19 (confirmed by reverse-transcriptase PCR (RT-PCR)) (table 1). All six patients had large vessel occlusion with markedly elevated D-dimer levels (1000g/L). Three patients had multiterritory infarcts, two had concurrent venous thrombosis, and, in two, ischaemic strokes occurred despite therapeutic anticoagulation.

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Идентификаторы

DOI: 10.1136/jnnp-2020-323586

Цитирования и источники

Цитирований: 3Использованных источников: 0

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