Phelligridimer A, a Highly Oxygenated and Unsaturated 26-Membered Macrocyclic Metabolite with Antioxidant Activity from the Fungus <i>Phellinus igniarius</i>
Ying WangInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China, and Key Laboratory for Atmospheric Chemistry (LAC), Centre for Atmosphere Watch and Services (CAWAS), Chinese Academy of Meteorological Sciences (CAMS), CMA, Beijing 100081, People's Republic of ChinaSujuan WangInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China, and Key Laboratory for Atmospheric Chemistry (LAC), Centre for Atmosphere Watch and Services (CAWAS), Chinese Academy of Meteorological Sciences (CAMS), CMA, Beijing 100081, People's Republic of ChinaShunyan MoInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China, and Key Laboratory for Atmospheric Chemistry (LAC), Centre for Atmosphere Watch and Services (CAWAS), Chinese Academy of Meteorological Sciences (CAMS), CMA, Beijing 100081, People's Republic of ChinaShuai LiInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China, and Key Laboratory for Atmospheric Chemistry (LAC), Centre for Atmosphere Watch and Services (CAWAS), Chinese Academy of Meteorological Sciences (CAMS), CMA, Beijing 100081, People's Republic of ChinaYongchun YangInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China, and Key Laboratory for Atmospheric Chemistry (LAC), Centre for Atmosphere Watch and Services (CAWAS), Chinese Academy of Meteorological Sciences (CAMS), CMA, Beijing 100081, People's Republic of ChinaJian‐Gong ShiInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China, and Key Laboratory for Atmospheric Chemistry (LAC), Centre for Atmosphere Watch and Services (CAWAS), Chinese Academy of Meteorological Sciences (CAMS), CMA, Beijing 100081, People's Republic of China
2005en
ABI
Аннотация
[structure: see text] A highly oxygenated and unsaturated 26-membered macrocyclic metabolite, phelligridimer A (1), has been isolated from the Chinese medicinal fungus Phellinus igniarius. Its structure was elucidated by spectroscopic methods. A possible biogenesis of 1 mediated by the fungal metabolite hispidin was postulated. Phelligridimer A showed antioxidant activity (IC50 of 10.2 microM) but was inactive to several human cancer cell lines (IC50 > 50 microM) and enzymes PTP1B (IC50 > 25 microM) and thrombin (IC50 > 10 microM).
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