Synthesis, Structure, and Biological Activity of Palladium(II) Complexes with Some 1- and 2-Substituted Tetrazole Ligands
A. A. BatyrenkoSt. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, RussiaOlga V. MikolaichukSt. Petersburg State University, 199034, St. Petersburg, RussiaGayane K. OvsepyanSt. Petersburg State University, 199034, St. Petersburg, RussiaA. V. ProtasPavlov First St. Petersburg State Medical University, 197022, St. Petersburg, RussiaIlya V. KornyakovKola Scientific Center of the Russian Academy of Sciences, 184209, Apatity, RussiaЕ.В. ЛидерInstitute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220141, Minsk, BelarusYu. A. EreminaA. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, RussiaТ. С. ХлебниковаInstitute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220141, Minsk, BelarusФ. А. ЛахвичInstitute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220141, Minsk, BelarusРостислав Е. ТрифоновSt. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia
2021en
ABI
Аннотация
A series of palladium(II) complexes with 1H- and 2H-tetrazole ligands (2-isopropyl-5-R-2H-tetrazoles and 1H-tetrazol-1-ylcarboxylic acids) was synthesized. Structure of the obtained compounds was confirmed by 1H and 13C NMR spectroscopy, high-resolution mass spectrometry, and single crystal X-ray diffraction analysis. According to the spectrophotometry data, the complexes are weakly bound to DNA. The cytotoxic activity of the obtained palladium complexes was studied in vitro.
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