Обзорная статья

The role of exosomal noncoding RNAs in cancer

Yan XieDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, 410078, ChinaWei DangDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, 410078, ChinaSiwei ZhangDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, 410078, ChinaWenxing YueDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, 410078, ChinaLi YangDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, 410078, ChinaXingyu ZhaiDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, 410078, ChinaQijia YanDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, 410080, ChinaJianhong LuDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, 410078, China. [email protected]

2019en

ABI

Аннотация

Extracellular vesicles (EVs) membranes enclose nanosized vesicles with a size range of 30-150 nm and are plentiful in our body in both physiological and pathological conditions. Exosomes, a type of EV, are important mediators of intracellular communication among tumor cells, immune cells, and stromal cells. They can shuttle bioactive molecules, such as proteins, lipids, RNA, and DNA; however, the precise function of EVs remains largely unknown. In recent years, tumor-associated cargo in exosomes has been a hot topic in research, especially with respect to noncoding RNAs (ncRNAs). Herein, we review the role of exosomal ncRNAs, including miRNAs and long noncoding RNAs, in tumor biological processes. Clinically, exosomal ncRNAs may eventually become novel biomarkers and therapeutic targets in cancer progression.

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Идентификаторы

DOI: 10.1186/s12943-019-0984-4

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar