The Image Biomarker Standardization Initiative: Standardized Convolutional Filters for Reproducible Radiomics and Enhanced Clinical Insights
P. WhybraFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QAlex ZwanenburgFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QVincent AndrearczykFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QRoger SchaerFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QAditya ApteFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QAlexandre AyotteFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QBhakti BahetiFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QSpyridon BakasFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QAndrea BettinelliUniversity Hospital Carl Gustav CarusRonald BoellaardFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QLuca BoldriniFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QIrène BuvatFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QGary CookFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QFlorian DietscheUniversity Hospital Carl Gustav CarusN. DinapoliFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QHubert S. GabryśFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QVicky GohFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QMatthias GückenbergerFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QMathieu HattUniversity Hospital Carl Gustav CarusMahdi HosseinzadehFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QAditi IyerFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QJacopo LenkowiczFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QMahdi Ait Lhaj LoutfiFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QSteffen LöckFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QFrancesca MarturanoFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QOlivier MorinFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QChristophe NiocheFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QFanny OrlhacFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QSarthak PatiUniversity Hospital HeidelbergArman RahmimFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QSeyed Masoud RezaeijoFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QChristopher G RookyardFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QMohammad R. SalmanpourFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QAndreas SchindeleFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QIsaac ShiriFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QEmiliano SpeziFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QStephanie Tanadini‐LangFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QFlorent TixierFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QTaman UpadhayaFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QVincenzo ValentiniFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QJoost J. M. van GriethuysenFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QFereshteh YousefiriziFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QHabib ZaidiUniversity Hospital Carl Gustav CarusHenning MüllerFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QMartin VallièresFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QAdrien DepeursingeFrom the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, Q
2024en
ABI
Аннотация
Filters are commonly used to enhance specific structures and patterns in images, such as vessels or peritumoral regions, to enable clinical insights beyond the visible image using radiomics. However, their lack of standardization restricts reproducibility and clinical translation of radiomics decision support tools. In this special report, teams of researchers who developed radiomics software participated in a three-phase study (September 2020 to December 2022) to establish a standardized set of filters. The first two phases focused on finding reference filtered images and reference feature values for commonly used convolutional filters: mean, Laplacian of Gaussian, Laws and Gabor kernels, separable and nonseparable wavelets (including decomposed forms), and Riesz transformations. In the first phase, 15 teams used digital phantoms to establish 33 reference filtered images of 36 filter configurations. In phase 2, 11 teams used a chest CT image to derive reference values for 323 of 396 features computed from filtered images using 22 filter and image processing configurations. Reference filtered images and feature values for Riesz transformations were not established. Reproducibility of standardized convolutional filters was validated on a public data set of multimodal imaging (CT, fluorodeoxyglucose PET, and T1-weighted MRI) in 51 patients with soft-tissue sarcoma. At validation, reproducibility of 486 features computed from filtered images using nine configurations × three imaging modalities was assessed using the lower bounds of 95% CIs of intraclass correlation coefficients. Out of 486 features, 458 were found to be reproducible across nine teams with lower bounds of 95% CIs of intraclass correlation coefficients greater than 0.75. In conclusion, eight filter types were standardized with reference filtered images and reference feature values for verifying and calibrating radiomics software packages. A web-based tool is available for compliance checking.
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