Modeling of regulatory mechanisms of oncogenic viruses Micro-RNA action

Abstract The article is devoted to investigate the dynamics of the regulatory mechanisms of viral miRNA during oncogenesis at Hepatitis B virus infection. Studies show that mutually conjugated molecular-genetic systems of hepatocytes and micro-RNA of oncogenic viruses have the following domains: a stable functional activity, the possibility of oscillatory modes of functioning, irregular oscillations (it may occur the chaotic behavior of oncoviruses micro-RNA and their regulatory network connections, which leads to chaotic uncontrolled cellular reproduction and cancer) and black hole effect (sharp reduction in the number of cells, which corresponds to the metastasis of cancer cells). The results of computational experiments show that depending on the parameters of the cell and the cellular external environment, some miRNAs can both activate and inhibit tumor growth.

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