Chemiluminescent carbon nanodots as sensors for hydrogen peroxide and glucose

Abstract Hydrogen peroxide (H 2 O 2 ) is an important product generated in the body and related to many pathophysiological processes and glucose metabolism disorder can cause many fatal diseases in living bodies. Therefore, the sensing of H 2 O 2 and glucose is of great significance in disease diagnostics and treatment. Fluorescent carbon dots (CDs) are one new class of nanoprobes for H 2 O 2 and glucose. Nevertheless, the CD‐based sensor is always based on its fluorescence response, which is influenced by the auto‐fluorescent interference. Herein, efficient fluorescent CDs were synthesized by one‐pot solvothermal method, and the CDs exhibit bright and persistent deep‐red (DR) chemiluminescence (CL) in bis(2,4,6‐trichlorophenyl) oxalate and H 2 O 2 solution with a CL quantum yield of (8.22 ± 0.30) × 10 −3 , which is amongst the highest values in ever reported nanomaterials for chemical analysis. Employing the CDs as CL nanoprobes, sensitive sensing for H 2 O 2 has been achieved with a detection limit of 11.7 μM, and further for glucose detection with a detection limit of 12.6 μM. The DR CL CDs is promising to be applied in blood glucose analysis or in vivo biosensor.

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