Synthesis, antimicrobial and antioxidant activity of bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl) methane

Abstract A series of new bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl)methane 3 ( a–d )/ 5 ( a–f ) were synthesized from bis‐(4‐aminophenyl)methane ( 1 ) using various pharmacologically active sulfonyl chlorides 2 ( a–d ) and carbonochloridates 4 ( a–f ) in high yields. The structures of all the newly synthesized compounds were characterized by the Infrared spectroscopy, NMR ( 1 H and 13 C), mass, and elemental analyses. Further, all the synthesized compounds were tested for the antioxidant activity by using 2, 2‐diphenyl‐1‐picrylhydrazyl, NO, and H 2 O 2 scavenging methods and antimicrobial activity. Most of the compounds exhibited good antioxidant and antimicrobial activities.

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