Utilization of CO<sub>2</sub> as a C1 Building Block in a Tandem Asymmetric A<sup>3</sup> Coupling-Carboxylative Cyclization Sequence to 2-Oxazolidinones
Xiaotong GaoChen-Chen GanSi-Yue LiuCollege
of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. ChinaFeng ZhouHaihong WuJian ZhouState
Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032, P. R. China
2017en
ABI
Аннотация
We report a tandem asymmetric aldehyde–alkyne–amine (A3) coupling-carboxylative cyclization sequence for the highly enantioselective synthesis of chiral N-aryl 2-oxazolidinones. This is a rare example of a multicatalyst-promoted asymmetric tandem reaction using CO2 as a C1 synthon. Notably, the copper species and ligand from the upstream A3 reaction are internally reused to facilitate the downstream silver-catalyzed carboxylative cyclization.
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