Статья

Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite

Maria Rosaria RicciardiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, ItalyRoberto LicchettaDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, ItalySimone MirabiliiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, ItalyMarzia ScarpariDepartment of Plant Biology, Sapienza University of Rome, Rome, ItalyAlessia ParroniDepartment of Plant Biology, Sapienza University of Rome, Rome, ItalyAndrea FabbriDepartment of Plant Biology, Sapienza University of Rome, Rome, ItalyPaola CescuttiDepartment of Life Sciences, University of Trieste, Trieste, ItalyMassimo ReverberiDepartment of Plant Biology, Sapienza University of Rome, Rome, ItalyC. FanelliDepartment of Plant Biology, Sapienza University of Rome, Rome, ItalyAgostino TafuriDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy

2017en

ABI

Аннотация

Despite improvements that occurred in the last decades in the acute myeloid leukemia (AML) treatment, clinical results are still unsatisfactory. More effective therapies are required, and innovative approaches are ongoing, including the discovery of novel antileukemia natural compounds. Several studies have described the activity of extracts from mushrooms which produce compounds that exhibited immunological and antitumor activities. The latter has been demonstrated to be promoted in vitro by mushroom polysaccharides via induction of apoptosis. However, the antileukemia activity of these compounds on primary cells is still not reported. In the present study, we examined the in vitro effects of Tramesan (TR), a bioactive compound extracted from Trametes versicolor , on leukemic cell lines and primary cells. Our results demonstrated that TR induced a marked growth inhibition of leukemic cell lines and primary cells from AML patients. The antiproliferative effects of TR were associated in primary AML cells with a significant increase of apoptosis. No significant cytotoxic effects were observed in normal peripheral blood mononuclear cells (MNC) from healthy donors. Our data demonstrated a cytotoxic activity of TR on leukemia cells prompting further translational applications. Ongoing studies are elucidating the molecular mechanisms underlying its antileukemic activity.

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Идентификаторы

DOI: 10.1155/2017/5061639

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Цитирований: 2Использованных источников: 0

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