Flavonoid Compounds from the Leaves of<i>Kalanchoe prolifera</i>and Their Cytotoxic Activity against P-388 Murine Leukimia Cells
Lilis Siti AisyahDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Achmad Yani, University, Cimahi 40528, IndonesiaYenny Febriani YunDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Achmad Yani, University, Cimahi 40528, IndonesiaTati HerlinaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, IndonesiaEuis JulaehaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, IndonesiaAchmad ZainuddinDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, IndonesiaIda NurfaridaCentral Laboratory of Universitas Padjadjaran, Jatinangor 45363, IndonesiaAce Tatang HidayatCentral Laboratory of Universitas Padjadjaran, Jatinangor 45363, IndonesiaUnang SupratmanCentral Laboratory of Universitas Padjadjaran, Jatinangor 45363, IndonesiaYoshihito ShionoDepartment of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan
2017en
ABI
Аннотация
Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-β-D-glucopyranoside (3), kaempferol-3-O-β-D-glucopyranoside (4), kaempferol-3-O-α-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1–7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with IC50 values of 4.45 ± 0.05 and 6.28 ± 0.02 μg/mL, respectively.
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