Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
Christine N. SpencerDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJennifer L. McQuadeDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAVancheswaran GopalakrishnanDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJohn A. McCullochLaboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USAMarie VétizouLaboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USAAlexandria P. CogdillDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMd Abdul Wadud KhanDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAXiaotao ZhangDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMichael G. WhiteDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAChristine B. PetersonDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMatthew C. WongDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAGolnaz MoradDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USATheresa RodgersDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJonathan H. BadgerLaboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USABeth A. HelminkDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMiles C. AndrewsDepartment of Medicine, Monash University, Melbourne, VIC 3004, AustraliaRichard R. RodriguesFrederick National Laboratory for Cancer Research, and Microbiome and Genetics Core, Laboratory of Integrative Cancer Immunology, CCR, NCI, NIH, Bethesda, MD 20852, USAAndrey MorgunDepartment of Pharmaceutical Science, Oregon State University, Corvallis, OR 97331, USAYoung S. KimNutritional Science Research Group, Division of Cancer Prevention, NCI, NIH, Rockville, MD 20850, USAJason RoszikDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAKristi L. HoffmanDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USAJiali ZhengDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAYifan ZhouDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAYusra B. MedikDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USALaura M. KahnDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASarah B. JohnsonDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USACourtney W. HudgensDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAKhalida WaniDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAPierre-Olivier GaudreauCanadian Cancer Trials Group and Department of Oncology, Queen’s University, Kingston, ON K7L 3N6, CanadaAngela L. HarrisCenter for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMohamed A. JamalDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAErez N. BaruchDepartment of Internal Medicine, The University of Texas Health Science Center, Houston, TX 77030, USAEva Pérez‐GuijarroChi‐Ping DayGlenn MerlinoBarbara PazdrakDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USABrooke S. LochmannDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USARobert Szczepaniak‐SloaneDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAReetakshi AroraDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJaime AndersonDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAChrystia M. ZobniwDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAEliza PosadaDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAElizabeth SirmansDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJulie M. SimonDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USALauren E. HayduDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAElizabeth M. BurtonDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USARuiping WangDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMinghao DangDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAKaren Clise-DwyerAdvanced Cytometry and Sorting Facility at South Campus, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASarah SchneiderAdvanced Cytometry and Sorting Facility at South Campus, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAThomas ChapmanDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USANana-Ama A.S. AnangDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASheila DuncanDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJoseph TokerDepartment of Oncology, University of Cambridge, Cambridge CB2 1TN, UKJared MalkeDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAIsabella C. GlitzaDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USARodabe N. AmariaDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAHussein A. TawbiDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAAdi DiabDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMichael K. WongDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASapna P. PatelDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAScott E. WoodmanDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMichael A. DaviesDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMerrick I. RossDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJeffrey E. GershenwaldDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJeffrey E. LeeDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAPatrick HwuDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAV. Behrana JensenDepartment of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAYardena SamuelsDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, IsraelRavid StraussmanDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, IsraelNadim J. AjamiDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAKelly C. NelsonDepartment of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USALuigi NeziDipartimento di Oncologia Sperimentale, Instituto Europeo di Oncologia, Milan, P.I. 08691440153, ItalyJoseph F. PetrosinoDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USAP. Andrew FutrealDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAAlexander J. LazarDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJianhua HuDepartment of Biostatistics, Columbia University, New York, NY 10032, USARobert R. JenqDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMichael T. TetzlaffDepartments of Pathology and Dermatology, Dermatopathology and Oral Pathology Unit, University of California San Francisco, San Francisco, CA 94115, USAYan YanDepartment of Biostatistics and the Harvard T.H. Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USAWendy S. GarrettDepartment of Molecular Metabolism, T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USACurtis HuttenhowerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USAPadmanee SharmaDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAStephanie S. WatowichDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJames P. AllisonDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USALorenzo CohenDepartment of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAGiorgio TrinchieriLaboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USACarrie R. DanielDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAJennifer A. WargoDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2021en
ABI
Аннотация
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but the effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, and commercially available probiotic supplement use in melanoma patients and performed parallel preclinical studies. Higher dietary fiber was associated with significantly improved progression-free survival in 128 patients on ICB, with the most pronounced benefit observed in patients with sufficient dietary fiber intake and no probiotic use. Findings were recapitulated in preclinical models, which demonstrated impaired treatment response to anti–programmed cell death 1 (anti–PD-1)–based therapy in mice receiving a low-fiber diet or probiotics, with a lower frequency of interferon-γ–positive cytotoxic T cells in the tumor microenvironment. Together, these data have clinical implications for patients receiving ICB for cancer.
Перевод пока недоступен
Идентификаторы
Цитирования и источники
Цитирований: 2Использованных источников: 0