Обзорная статья

Recent Advances in Lipid Nanoparticles and Their Safety Concerns for mRNA Delivery

Jialiang WangMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USAYaopeng DingMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USAK. Chul ChongSmith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USAMeng CuiDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USAZeyu CaoDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USAChenjue TangMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USAZhen TianDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USAYuping HuSmith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USAYu ZhaoMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USAShaoyi JiangMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA

2024en

ABI

Аннотация

INTRODUCTION: The advent of lipid nanoparticles (LNPs) as a delivery platform for mRNA therapeutics has revolutionized the biomedical field, particularly in treating infectious diseases, cancer, genetic disorders, and metabolic diseases. Recent Advances in Therapeutic LNPs: LNPs, composed of ionizable lipids, phospholipids, cholesterol, and polyethylene glycol (PEG) lipids, facilitate efficient cellular uptake and cytosolic release of mRNA while mitigating degradation by nucleases. However, as synthetic entities, LNPs face challenges that alter their therapeutic efficacy and safety concerns. Toxicity/Reactogenicity/Immunogenicity: This review provides a comprehensive overview of the latest advancements in LNP research, focusing on preclinical safety assessments encompassing toxicity, reactogenicity, and immunogenicity. Summary and Outlook: Additionally, it outlines potential strategies for addressing these challenges and offers insights into future research directions for enhancing the application of LNPs in mRNA therapeutics.

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Идентификаторы

DOI: 10.3390/vaccines12101148

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar