Обзорная статья

“Double-sided protector” Janus hydrogels for skin and mucosal wound repair: applications, mechanisms, and prospects

Laijun XuGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, 510515, ChinaJunyi ZhangHunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, ChinaJunsi LuoGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, 510515, ChinaYiteng CuiHunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, ChinaJinhong ChenGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, 510515, ChinaBin ZengSchool of Stomatology, Changsha Medical University, Changsha, 410219, ChinaZhiyuan DengHunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, 410000, China. [email protected]Longquan ShaoGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, 510515, China. [email protected]

2025en

ABI

Аннотация

Skin and mucous membranes serve as crucial barrier tissues within the human body. Defective wound healing not only inflicts pain but also heightens the risk of infection and impairs immune function. Janus hydrogels possess two-sided distinct asymmetric structures that endow them with diverse properties such as high water absorbency, flexibility, anti-adhesion ability etc. These hydrogels also exhibit great potential in biofluid transport, drug delivery and promoting tissue repair. Currently, research efforts predominantly concentrate on the preparation techniques, properties, and biomedical applications. This review summarized its structural characteristics and different forms of designations, and focused on the possible mechanisms, the existing problems and improvement strategies for the skin and mucous tissues wound, aiming to provide new design ideas for repairing complex skin and mucous membrane tissue defects.

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Идентификаторы

DOI: 10.1186/s12951-025-03438-3

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar