Статья

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis

Xiao ZhengDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaXing SongDepartment of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaYingjie ShaoDepartment of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaBin XuDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaLujun ChenDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaQi ZhouDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaWenwei HuDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaDachuan ZhangDepartment of Pathology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaChangping WuDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of ChinaMin TaoInstitute of Cell Therapy, Soochow University, Changzhou 213003, People's Republic of ChinaYibei ZhuInstitute of Cell Therapy, Soochow University, Changzhou 213003, People's Republic of ChinaJingting JiangDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of China

2017en

ABI

Аннотация

BACKGROUND: In patients with gastric cancer, the prognostic value of tumor-infiltrating lymphocytes (TILs) is still controversial. A meta-analysis was performed to evaluate the prognostic value of TILs in gastric cancer. MATERIALS AND METHODS: We identify studies from PubMed, Embase and the Cochrane Library to assess the prognostic effect of TILs in patients with gastric cancer. Fixed-effects models or random-effects models were used estimate the pooled hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS), which depend on the heterogeneity. RESULTS: = 0.022). CONCLUSIONS: This meta-analysis suggests that some TIL subsets could serve as prognostic biomarkers in gastric cancer. High-quality randomized controlled trials are needed to decide if these TILs could serve as targets for immunotherapy in gastric cancer.

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Идентификаторы

DOI: 10.18632/oncotarget.18065

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar