Статья

<i>Akkermansia muciniphila</i> induces intestinal adaptive immune responses during homeostasis

Eduard AnsaldoDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USALeianna C. SlaydenDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USAKrystal L. ChingDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USAMeghan A. KochDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USANatalie K. WolfDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USADamian R. PlichtaBroad Institute of MIT and Harvard, Cambridge, MA, USAEric BrownBroad Institute of MIT and Harvard, Cambridge, MA, USADaniel B. GrahamBroad Institute of MIT and Harvard, Cambridge, MA, USARamnik J. XavierBroad Institute of MIT and Harvard, Cambridge, MA, USAJames J. MoonCenter for Immunology and Inflammatory Diseases and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USAGregory M. BartonDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA

2019en

ABI

Аннотация

Context shapes anticommensal immunity The gut bacterium Akkermansia muciniphila is associated with protection from obesity, enhanced wound healing, and augmented antitumor responses. Ansaldo et al. found that this microbe induces antigen-specific immunoglobulin G1 (IgG1) antibodies generated by B cells with CD4 + T cell help. This is in contrast to most anticommensal responses, which involve the T cell–independent production of IgA antibodies. In a gnotobiotic setting in which all components of the microbiome are defined, A. muciniphila –specific T cells expanded only when A. muciniphila was present. The T cells primarily displayed a phenotype associated with B cell help. However, in mice with a conventional gut microbiota, other proinflammatory A. muciniphila –specific T cell populations also expanded. Thus, anti– A. muciniphila immunity is context dependent, which may explain the variable immune responses to this microbe reported in patients. Science , this issue p. 1179

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Идентификаторы

DOI: 10.1126/science.aaw7479

Цитирования и источники

Цитирований: 2Использованных источников: 0

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