Статья

Increased Intramyocellular Lipid Concentration Identifies Impaired Glucose Metabolism in Women With Previous Gestational Diabetes

Alexandra Kautzky‐WillerDepartment of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, AustriaMartin KrššákDepartment of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, AustriaChristine WinzerDepartment of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, AustriaGiovanni PaciniMetabolic Unit, Institute of Biomedical Engineering, National Research Council (ISIB-CNR), Padova, ItalyAndrea TuraMetabolic Unit, Institute of Biomedical Engineering, National Research Council (ISIB-CNR), Padova, ItalySerdar FarhanDepartment of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, AustriaOswald WagnerInstitute for Medical Laboratory Diagnostics, University of Vienna, Vienna, AustriaGeorg BrabantDivision of Endocrinology, University of Hannover, Hannover, GermanyR. HornDivision of Endocrinology, University of Hannover, Hannover, GermanyHarald StinglDepartment of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, AustriaBarbara SchneiderInstitute of Biostatistics, University of Vienna, Vienna, AustriaW. WaldhäuslDepartment of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, AustriaMichael RodenDepartment of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, Austria

2003en

ABI

Аннотация

Women with previous gestational diabetes (pGDM) are frequently insulin-resistant, which could relate to intramyocellular lipid content (IMCL). IMCL were measured with (1)H nuclear magnetic resonance spectroscopy in soleus (IMCL-S) and tibialis-anterior muscles (IMCL-T) of 39 pGDM (32 +/- 2 years, waist-to-hip ratio 0.81 +/- 0.01) and 22 women with normal glucose tolerance (NGT; 31 +/- 1 years, 0.76 +/- 0.02) at 4-6 months after delivery. Body fat mass (BFM) was assessed from bioimpedance analysis, insulin sensitivity index (S(I)), and glucose effectiveness (S(G)) from insulin-modified frequently sampled glucose tolerance tests. pGDM exhibited 45% increased BFM, 35% reduced S(I) and S(G) (P < 0.05), and 40% (P < 0.05) and 55% (P < 0.005) higher IMCL-S and IMCL-T, respectively. IMCL related to body fat (BFM P < 0.005, leptin P < 0.03), but only IMCL-T correlated (P < 0.03) with S(I) and glucose tolerance index independent of BMI. Insulin-resistant pGDM (n = 17) had higher IMCL-S (+66%) and IMCL-T (+86%) than NGT and insulin-sensitive pGDM (+28%). IMCL were also higher (P < 0.005, P = 0.05) in insulin-sensitive pGDM requiring insulin treatment during pregnancy and inversely related to the gestational week of GDM diagnosis. Thus, IMCL-T reflects insulin sensitivity, whereas IMCL-S relates to obesity. IMCL could serve as an additional parameter of increased diabetes risk because it identifies insulin-resistant pGDM and those who were diagnosed earlier and/or required insulin during pregnancy.

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Идентификаторы

DOI: 10.2337/diabetes.52.2.244

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar