Статья

SWISS-MODEL: homology modelling of protein structures and complexes

Andrew WaterhouseBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandMartino BertoniBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandStefan BienertBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandGabriel StuderBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandGerardo TaurielloBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandRafal GumiennyBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandFlorian HeerBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandTjaart de BeerBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandChristine RempferBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandLorenza BordoliBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandRosalba LeporeBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, SwitzerlandTorsten SchwedeBiozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, Switzerland

2018en

ABI

Аннотация

Homology modelling has matured into an important technique in structural biology, significantly contributing to narrowing the gap between known protein sequences and experimentally determined structures. Fully automated workflows and servers simplify and streamline the homology modelling process, also allowing users without a specific computational expertise to generate reliable protein models and have easy access to modelling results, their visualization and interpretation. Here, we present an update to the SWISS-MODEL server, which pioneered the field of automated modelling 25 years ago and been continuously further developed. Recently, its functionality has been extended to the modelling of homo- and heteromeric complexes. Starting from the amino acid sequences of the interacting proteins, both the stoichiometry and the overall structure of the complex are inferred by homology modelling. Other major improvements include the implementation of a new modelling engine, ProMod3 and the introduction a new local model quality estimation method, QMEANDisCo. SWISS-MODEL is freely available at https://swissmodel.expasy.org.

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Идентификаторы

DOI: 10.1093/nar/gky427

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar