An in vitro study of cytotoxic effects of gossypol on human epidermoid larynx carcinoma cell line (HEp-2).

AIM: The study was aimed on an evaluation of the effect of gossypol at concentration of 25-150 microM on the level of apoptosis in the human epidermoid larynx carcinoma cell line, HEp-2, in vitro. METHODS: To determine the apoptotic effects of gossypol on growth of human epidermoid larynx carcinoma cell lines (HEp-2 cells), morphological evaluation of the cells and DNA fragmentation analysis were used. RESULTS: 6 h incubation of HEp-2 cells with gossypol at concentrations of 50 microM and 75 microM resulted in the increase of apoptosis rate by 26 and 23%, respectively. CONCLUSION: This preliminary study may constitute a base for in vivo studies of anticancer properties of gossypol.

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