Silver sulfadiazine–immobilized celluloses as biocompatible polymeric biocides

Sulfadiazine was immobilized onto cotton cellulose using ethylene glycol diglycidyl ether as a binder. Upon treatment with diluted silver nitrate aqueous solution, the sulfadiazine moieties in the immobilized celluloses were transformed into silver–sulfadiazine coordination complexes. The resulting silver sulfadiazine–immobilized celluloses provided a 6-log reduction of 10 8 CFU mL −1 of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), methicillin-resistant Staphylococcus aureus (drug-resistant bacteria), vancomycin-resistant Enterococcus faecium (drug-resistant bacteria), and Candida albicans (fungi) in 30–60 minutes, and a 5-log reduction of 10 7 PFU mL −1 of MS2 virus in 120 minutes. The antibacterial, antifungal, and antiviral activities were both durable and rechargeable. Additionally, trypan blue assay suggested that the new silver sulfadiazine–immobilized celluloses sustained excellent mammal cell viability, pointing to great potentials of the new materials for a broad range of health care–related applications.

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