Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s
D. DoriaQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKK. F. KakoleeQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKS. KarQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKS. K. LittQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKF. FioriniUniversity of Birmingham 2 School of Physics and Astronomy, , B15 2TT, UKH. AhmedQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKS. GreenUniversity Hospital Birmingham 3 Hall Edwards Radiotherapy Research Group, Dept. of Medical Physics, , B15 2TH, UKJ. Charles G. JeynesUniversity of Surrey 4 Ion Beam Centre, Advanced Technology Institute, , Guildford GU2 7XH, UKJoy N. KavanaghQueen's University Belfast 5 Centre for Cancer Research and Cell Biology, , BT9 7BL, UKD. KirbyUniversity of Birmingham 2 School of Physics and Astronomy, , B15 2TT, UKK.J. KirkbyUniversity of Surrey 4 Ion Beam Centre, Advanced Technology Institute, , Guildford GU2 7XH, UKC. L. S. LewisQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKMichael J. MerchantUniversity of Surrey 4 Ion Beam Centre, Advanced Technology Institute, , Guildford GU2 7XH, UKG. NersisyanQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKR. PrasadQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKKevin M. PriseQueen's University Belfast 5 Centre for Cancer Research and Cell Biology, , BT9 7BL, UKGiuseppe SchettinoQueen's University Belfast 5 Centre for Cancer Research and Cell Biology, , BT9 7BL, UKM. ZepfQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UKM. BorghesiQueen's University Belfast 1 Centre for Plasma Physics, , BT7 1NN, UK
2012en
ABI
Аннотация
The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.
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