Статья

Folate-Targeted Curcumin-Loaded Niosomes for Site-Specific Delivery in Breast Cancer Treatment: In Silico and In Vitro Study

Banafsheh HonarvariDepartment of Physics, Faculty of Physics and Chemistry, Alzahra University, Tehran 1993893973, IranSara KarimifardCentral Tehran Branch, Stem Cells Research Center, Tissue Engineering and Regenerative Medicine Institute, Islamic Azad University, Tehran 1568937813, IranNiyayesh AkhtariDepartment of Biology, Parand Branch, Islamic Azad University, Parand 3761396361, IranMehrnoush MehraryaProtein Research Center, Shahid Beheshti University, Tehran 1983969411, IranZahra Salehi MoghaddamDepartment of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Tehran 141556455, IranMohammad Javed AnsariDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 16278, Saudi ArabiaAbduladheem Turki JalilMedical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla 51001, IraqAdrián MatencioDepartment of Chemistry, University of Turin, Via Pietro Giuria 7, 10125 Torino, ItalyFrancesco TrottaDepartment of Chemistry, University of Turin, Via Pietro Giuria 7, 10125 Torino, ItalyFaten Eshrati YeganehDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Tehran 14515775, IranBahareh Farasati FarResearch Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Tehran 1684611367, IranMandana Kazem ArkiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19835178, IranMohammad Reza Naimi‐JamalResearch Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Tehran 1684611367, IranHassan NoorbazarganDepartment of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, IranZahra Asghari LalamiDepartment of Biology, Parand Branch, Islamic Azad University, Parand 3761396361, IranMohsen ChianiNew Technology Research Group, Department of Nano Biotechnology, Pasteur Institute of Iran, Tehran 1316943551, Iran

2022en

ABI

Аннотация

As the most common cancer in women, efforts have been made to develop novel nanomedicine-based therapeutics for breast cancer. In the present study, the in silico curcumin (Cur) properties were investigated, and we found some important drawbacks of Cur. To enhance cancer therapeutics of Cur, three different nonionic surfactants (span 20, 60, and 80) were used to prepare various Cur-loaded niosomes (Nio-Cur). Then, fabricated Nio-Cur were decorated with folic acid (FA) and polyethylene glycol (PEG) for breast cancer suppression. For PEG-FA@Nio-Cur, the gene expression levels of Bax and p53 were higher compared to free drug and Nio-Cur. With PEG-FA-decorated Nio-Cur, levels of Bcl2 were lower than the free drug and Nio-Cur. When MCF7 and 4T1 cell uptake tests of PEG-FA@Nio-Cur and Nio-Cur were investigated, the results showed that the PEG-FA-modified niosomes exhibited the most preponderant endocytosis. In vitro experiments demonstrate that PEG-FA@Nio-Cur is a promising strategy for the delivery of Cur in breast cancer therapy. Breast cancer cells absorbed the prepared nanoformulations and exhibited sustained drug release characteristics.

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Идентификаторы

DOI: 10.3390/molecules27144634

Цитирования и источники

Цитирований: 2Использованных источников: 0

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