Обзорная статья

The role of miRNAs in colorectal cancer progression and chemoradiotherapy

Ning ZhangSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, ChinaXianyu HuSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, ChinaYinan DuSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, China. Electronic address: [email protected]Juan DuLonggang District People's Hospital of Shenzhen & The Third Affiliated Hospital (Provisional) of The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, China. Electronic address: [email protected]

2020en

ABI

Аннотация

Colorectal cancer (CRC) is known as the third most common cancer as well as the fourth most deadly cancer worldwide. CRC accounts for approximately 10 % of all new cancer cases globally, remaining the second most frequent cause of cancer-related deaths. MicroRNAs (miRNAs) are a class of small noncoding RNAs that can affect a variety of cellular and molecular targets. Depending on the cell environment in which the information is expressed, miRNAs can serve as a CRC suppressor or promoter and play essential roles in several biological processes. In this review, we summarized the relationship between miRNAs and proliferation, metastasis, angiogenesis, autophagy, apoptosis, and the chemoradiotherapy of CRC, revealing that relevant miRNAs could serve as potential targets for CRC therapy.

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Идентификаторы

DOI: 10.1016/j.biopha.2020.111099

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar