Статья

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

Benjamin Kefas1Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia;Jakub Godlewski2Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, Ohio State University Medical Center, Columbus, Ohio; andLaurey Comeau1Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia;Yunqing Li1Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia;Roger Abounader1Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia;Michael P. Hawkinson1Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia;Jeongwu Lee3Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda, MarylandHoward A. Fine3Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda, MarylandE. Antonio Chiocca2Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, Ohio State University Medical Center, Columbus, Ohio; andSean Lawler2Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, Ohio State University Medical Center, Columbus, Ohio; andBenjamin Purow1Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia;

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ABI

Аннотация

microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways. miR-7 potently suppressed epidermal growth factor receptor expression, and furthermore it independently inhibited the Akt pathway via targeting upstream regulators. miR-7 expression was down-regulated in glioblastoma versus surrounding brain, with a mechanism involving impaired processing. Importantly, transfection with miR-7 decreased viability and invasiveness of primary glioblastoma lines. This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma.

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Идентификаторы

DOI: 10.1158/0008-5472.can-07-6639

Цитирования и источники

Цитирований: 2Использованных источников: 0

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