Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol
Tao LinDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510Raymond F. SchinaziDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510Brigitte P. GriffithDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510Elias AugustDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510B. ErikssonDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510Dongge ZhengDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510Lin HuangDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510William H. PrusoffDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510
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ABI
Аннотация
The (-) enantiomer of gossypol but not the (+) enantiomer had good antiviral activity in peripheral blood mononuclear cells against human immunodeficiency virus type 1 at a concentration more than 20-fold lower than that required for cytotoxicity; however, in H9 cells the (-) enantiomer, although more potent as an antiviral agent, was more cytotoxic.
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