Polysulfide Derivatives from <i>Ferula foetida</i>
Hong‐Quan DuanThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,Yoshihisa TakaishiThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,Motoo ToriThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,Shigeru TakaokaThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,Gisho HondaThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,Michiho ItoThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,Yoshio TakedaThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,Olimjon K. KodzhimatovThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,K. KodzhimatovThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,Ozodbek AshurmetovThe College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China, Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Sakyou-ku, Kyoto 606-8501, Japan, Faculty of Integrated Arts and Sciences, University of Tokushima,
2002en
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Аннотация
The ethyl acetate-soluble fraction from a methanol extract of Ferula foetida has afforded six new sulfide derivatives, (E)-3-methylsulfinyl-2-propenyl sec-butyl disulfide (foetisulfide A) (1), (Z)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide B) (2), (E)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide C) (3), bis(3-methylthio-2E-propenyl) disulfide (foetisulfide D) (4), 3,4,5-trimethyl-2-thiophenecarboxylic acid (foetithiophene A) (5), 3,4,5-trimethyl-2-(methylsulfinyloxymethyl)thiophene (foetithiophene B) (6), along with six known compounds. The structures of 1-6 were established on the basis of spectroscopic studies, with the elucidation of 5 confirmed by single-crystal X-ray crystallography.
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