New sources of 9‐<scp>d</scp>‐hydroxy‐<i>cis</i>‐12‐octadecenoic acid

Abstract 9‐ d ‐Hydroxy‐ cis ‐12‐octadecenoic acid has been isolated from 3 seed oils of the family Apocynaceae: Holarrhena antidysenterica (73%), Nerium oleander (11%) and Nerium indicum (8%). The known occurrence of this acid was previously limited to the genus Strophanthus (9–15%). A mixture of unusual tetra‐acid glycerides was isolated from N. oleander oil by thin layer chromatography. Pancreatic lipase hydrolysis of the glyceride mixture showed that 9‐ d ‐acetoxy‐ cis ‐12‐octadecenoic acid is esterified exclusively at an α‐glycerol position and that normal fatty acids occupy the remaining 2 glycerol positions. A portion of the hydroxy acid in N. indicum oil was also acetylated, however, no acetate was found in either H. antidysenterica or Strophanthus hispidus oils.

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