3-Hydroxymethylidene-1,2,3,9-tetrahydropyrrolo(2,1-b)-quinazolin-9-one and 4-(formyl)-1,2,3,4,10-pentahydropyrido(2,1-b)-quinazolin-10-one - new sintons for obtaining of 3,4-dihydroisoquinolines

The reaction of 3-hydroxymethylidene-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-9one (3) and 4-(formyl-1,2,3,4,10-pentahydropyrido[2,1-b]-quinazoline-10-one (4) amination with homoverathryl- (5a) and homopyperanilamine (5b) studied. New heterocyclic derivatives of quinazolines 3-(3,4-dimethoxyphenylethylamino)-methylidene1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazolin-9-one (6a), 3-(3,4-methylene dioxypheny lethylamino) -methylidene-1,2,3,9-tetra hydropyrrolo[2,1-b]-quinazolin-9-one (6b), 4(3,4-di methoxy phenyl ethylamino) -methylidene-1,2,3,4,10 –penta hydropyrido[2,1-b]quinazolin-10-one (6c), 4-(3,4-methylenedioxyphenylethylamino)-methylidene-1,2,3,4,10pentahydropyrido[2,1-b]-quinazolon-10-one (6d) synthesized. Interaction of the obtained heterocyclic derivatives 6a-d to trifluoroacetic acid gave the corresponding 3, 4dihydroisoquinolines (7a, b), deoxyvasicinone (1) and mackinazolinone (2) instead of expected products of cyclization.

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