Статья

Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization

Boris MandićFaculty of Chemistry University of Belgrade, Studentski trg 16, Belgrade 11158, SerbiaMilena SimićFaculty of Pharmacy University of Belgrade, Vojvode Stepe 450, Belgrade 11000, SerbiaIvan VučkovićFaculty of Chemistry University of Belgrade, Studentski trg 16, Belgrade 11158, SerbiaLjubodrag VujisićFaculty of Chemistry University of Belgrade, Studentski trg 16, Belgrade 11158, SerbiaMiroslav NovakovićInstitute of Chemistry, Technology and Metallurgy University of Belgrade, Njegoseva 12, Belgrade 11000, SerbiaSnežana TrifunovićFaculty of Chemistry University of Belgrade, Studentski trg 16, Belgrade 11158, SerbiaSnežana Nikolić-MandićFaculty of Chemistry University of Belgrade, Studentski trg 16, Belgrade 11158, SerbiaVele TeševićFaculty of Chemistry University of Belgrade, Studentski trg 16, Belgrade 11158, SerbiaVlatka VajsInstitute of Chemistry, Technology and Metallurgy University of Belgrade, Njegoseva 12, Belgrade 11000, SerbiaSlobodan MilosavljevićFaculty of Chemistry University of Belgrade, Studentski trg 16, Belgrade 11158, Serbia

2013en

ABI

Аннотация

The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (¹H- and ¹³C-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.

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Идентификаторы

DOI: 10.3390/molecules180910694

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