Статья

Acetyl Eburicoic Acid from <i>Laetiporus sulphureus</i> var. <i>miniatus</i> Suppresses Inflammation in Murine Macrophage RAW 264.7 Cells

Evelyn SabaLaboratory of Veterinary Physiology and Cell Signaling, Cardiovascular Research Institute and College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, KoreaYoungmin SonLaboratory of Veterinary Physiology and Cell Signaling, Cardiovascular Research Institute and College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, KoreaBo Ra JeonLaboratory of Veterinary Physiology and Cell Signaling, Cardiovascular Research Institute and College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, KoreaSeong‐Eun KimDivision of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, Iksan, 570-752, KoreaIn‐Kyoung LeeDivision of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, Iksan, 570-752, KoreaBong‐Sik YunDivision of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, Iksan, 570-752, KoreaMan Hee RheeLaboratory of Veterinary Physiology and Cell Signaling, Cardiovascular Research Institute and College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Korea

2015en

ABI

Аннотация

The basidiomycete Laetiporus sulphureus var. miniatus belongs to the Aphyllophorales, Polyporaceae, and grows on the needleleaf tree. The fruiting bodies of Laetiporus species are known to produce N-methylated tyramine derivatives, polysaccharides, and various lanostane triterpenoids. As part of our ongoing effort to discover biologically active compounds from wood-rotting fungi, an anti-inflammatory triterpene, LSM-H7, has been isolated from the fruiting body of L. sulphureus var. miniatus and identified as acetyl eburicoic acid. LSM-H7 dose-dependently inhibited the NO production in RAW 264.7 cells without any cytotoxicity at the tested concentrations. Furthermore it suppressed the production of proinflammatory cytokines, mainly inducible nitric oxide synthase, cyclooxygenase-2, interleukin (IL)-1β, IL-6 and tumor necrosis factor α, when compared with glyceraldehyde 3-phosphate dehydrogenase. These data suggest that LSM-H7 is a crucial component for the antiinflammatory activity of L. sulphureus var. miniatus.

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Идентификаторы

DOI: 10.5941/myco.2015.43.2.131

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar