Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
Peng WangCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaHui-Hui YuanCollege of Life Sciences, Nankai University, Tianjin 300071, ChinaXue ZhangCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaYunping LiCollege of Life Sciences, Nankai University, Tianjin 300071, ChinaLuqing ShangCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaYin ZhengCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
2014en
ABI
Аннотация
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
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