Zinc-Mediated Facile and Efficient Chemoselective<i>S</i>-Alkylation of 5-Aryl-1,3,4-oxadiazole-2-thiols in the Absence of Base
M. S. R. Murtya Organic Chemistry Division I, Indian Institute of Chemical Technology , Hyderabad, IndiaRayudu Venkateswara Raoa Organic Chemistry Division I, Indian Institute of Chemical Technology , Hyderabad, IndiaKesur R. Rama Organic Chemistry Division I, Indian Institute of Chemical Technology , Hyderabad, IndiaN. Rami Reddya Organic Chemistry Division I, Indian Institute of Chemical Technology , Hyderabad, IndiaJ. S. Yadava Organic Chemistry Division I, Indian Institute of Chemical Technology , Hyderabad, IndiaB. Sridharb Laboratory of X-ray Crystallography, Indian Institute of Chemical Technology , Hyderabad, India
2010en
ABI
Аннотация
Zinc-mediated facile and efficient chemoselective S-alkylation of 5-aryl 1,3,4-oxadiazole-2-thiols in the presence of a catalytic amount of tetra butyl ammonium iodide was described. The reaction was performed under neutral conditions. The chemoselectivity of the alkylation was confirmed by NMR spectroscopy and x-ray crystallography.
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