Machine Learning-Enhanced Analysis of Genomic Data for Precision Medicine

Precision medicine employs genetic data, which is enhanced with machine learning algorithms, to determine the most relevant treatment method per patient’s genotype. We have zoned in on the area of a machine learning-guided genetic information analysis in this study to assist in clinical decisionmaking of precision medicine while improvising. Genetic information for 500 cancer patients cases taken from the public database and cleaned to lean out the desired features were furnished. Different machine learning algorithms were trained, including SVM, random forest, gradient boost, deep learning (CNN) and ensemble (ensemble method). Their performance was investigated for predicting cancer subtypes. The ensemble model reached the top accuracy level ($88 \%$), the best sensitivity ($85 \%$), ever specificity ($91 \%$) and AUC score (0.95). By comparison a group had better result than an individual algorithm could across all metrics. In further, deep learning methods were reported to attain more accuracy and F1 scores which is more than traditional machine learning methods. These findings hence prequalify the usefulness of ML in investigating genotype data in precision medicine, and enable physicians with useful information to select treatment options, make prognosis, and indicate the medical care.

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