Обзорная статья

Tumor-related epilepsy: epidemiology, pathogenesis and management

Dillon Y. ChenDepartment of Neuroscience, University of California, San Diego, USAClark C. ChenDepartment of Neurology, University of Minnesota, Moos Tower 515 Delaware St SE, Suite 13-250, MMC 295 MAYO, Minneapolis, MN, 55455, USAJohn R. CrawfordDepartment of Neuroscience, University of California, San Diego, USASonya WangDepartment of Neurology, University of Minnesota, Moos Tower 515 Delaware St SE, Suite 13-250, MMC 295 MAYO, Minneapolis, MN, 55455, USA. [email protected]

2018en

ABI

Аннотация

INTRODUCTION: Seizure is a common comorbidity in patients with brain tumor. It may be the presenting symptom or develop after the tumor diagnosis. The underlying pathophysiology of brain tumor-related epilepsy remains poorly understood. METHODS: A comprehensive literature review of Pubmed English articles from 1980-2017 was performed to summarize current knowledge and treatment options of brain tumor-related epilepsy. RESULTS: Multiple factors have been found to contribute to tumor-related epilepsy, including tumor type, speed of tumor growth, location, and tumor burden. The underlying pathogenesis of epilepsy is not clear but perturbations in the peri-tumoral regions, both structural and cellular communications, have been implicated. CONCLUSIONS: Surgical and medical treatments of tumor-related epilepsy remain challenging as additional factors such as the extent of surgical resection, interactions with tumor-related oncological treatments and anti-epileptic medication related side effects need to be considered.

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Идентификаторы

DOI: 10.1007/s11060-018-2862-0

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar