Статья

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

Chih‐Jung Chang1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [3] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Gueishan, Taoyuan 33305, Taiwan, ROC [4] Department of Microbiology and Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [5] Research Center of Bacterial Pathogenesis, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROCChuan-Sheng Lin1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [3] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Gueishan, Taoyuan 33305, Taiwan, ROC [4] Research Center of Bacterial Pathogenesis, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROCChia‐Chen LuDepartment of Respiratory Therapy, Fu Jen Catholic University, Xinzhuang, New Taipei City 24205, Taiwan, ROCJan MartelCenter for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROCYun‐Fei Ko1] Chang Gung Biotechnology Corporation, Taipei 10508, Taiwan, ROC [2] Biochemical Engineering Research Center, Ming Chi University of Technology, Taishan, New Taipei City 24301, Taiwan, ROCDavid M. Ojcius1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, California 94103, USAShun‐Fu TsengResearch Center of Bacterial Pathogenesis, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROCTsung-Ru Wu1] Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Gueishan, Taoyuan 33305, Taiwan, ROCYi‐Ywan M. ChenDepartment of Microbiology and Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROCJohn Ding‐E Young1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Chang Gung Biotechnology Corporation, Taipei 10508, Taiwan, ROC [3] Biochemical Engineering Research Center, Ming Chi University of Technology, Taishan, New Taipei City 24301, Taiwan, ROC [4] Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021, USAHsin‐Chih Lai1] Center for Molecular and Clinical Immunology, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [2] Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC [3] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Gueishan, Taoyuan 33305, Taiwan, ROC [4] Research Center of Bacterial Pathogenesis, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, ROC

2015en

ABI

Аннотация

Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative anti-diabetic effects. Here, we show that a water extract of Ganoderma lucidum mycelium (WEGL) reduces body weight, inflammation and insulin resistance in mice fed a high-fat diet (HFD). Our data indicate that WEGL not only reverses HFD-induced gut dysbiosis-as indicated by the decreased Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels-but also maintains intestinal barrier integrity and reduces metabolic endotoxemia. The anti-obesity and microbiota-modulating effects are transmissible via horizontal faeces transfer from WEGL-treated mice to HFD-fed mice. We further show that high molecular weight polysaccharides (>300 kDa) isolated from the WEGL extract produce similar anti-obesity and microbiota-modulating effects. Our results indicate that G. lucidum and its high molecular weight polysaccharides may be used as prebiotic agents to prevent gut dysbiosis and obesity-related metabolic disorders in obese individuals.

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Идентификаторы

DOI: 10.1038/ncomms8489

Цитирования и источники

Цитирований: 4Использованных источников: 0

Показатели — AkademScholar