Статья

Anti-hydroxyl radical activity, redox potential and anti-AChE activity of <i>Amanita strobiliformis</i> polysaccharide extract

Maja KaramanFaculty of Sciences, Department of Biology and Ecology, University of Novi Sad, Novi Sad, SerbiaLjiljana JanjuševićFaculty of Sciences, Department of Biology and Ecology, University of Novi Sad, Novi Sad, SerbiaDragica JakovljevićInstitute of Chemistry, Technology and Metallurgy, Centre of Chemistry, University of Belgrade, Belgrade, SerbiaFilip ŠibulFaculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad, Novi Sad, SerbiaBoris PejinDepartment of Life Sciences, Institute for Multidisciplinary Research – IMSI, University of Belgrade, Belgrade, Serbia

2018en

ABI

Аннотация

This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of α and ß glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 ± 0.59 μg/mL) and high potential for reduction of Fe3+ ions (174.11 ± 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 μg), the same extract exhibited a moderate anti-AChE activity (10 μg) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 ± 0.31 μg/mL, 197.68 ± 9.47 mg eq. AA/g d.w. and 0.1 μg, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.

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Идентификаторы

DOI: 10.1080/14786419.2017.1422183

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar