[Clinico-biochemical effectiveness of emoxpine in patients with bacterial bronchial asthma].

AIM: To determine effectiveness of a synthetic antioxidant drug emoxipine in combined treatment of bacterial bronchial asthma (BBA). MATERIALS AND METHODS: A total of 59 BBA patients were treated who had the disease for 1-14 years. The previous treatment consisted of bronchodilating, mucolytic and expectorant drugs. 19 of them received i.m. adjuvant emoxipine for 10 days in daily dose 0.3 mg/kg as a 1% aqueous solution. Metabolic activity of alveolar macrophages (AM) was measured. RESULTS: Emoxipine-treated patients had reduced content of primary lipid peroxidation products and schiff bases in AM, catalase level in them returned to normal, blood levels of alpha-tocopherol went up. CONCLUSION: Emoxipine is beneficial for AM antioxidant defence system in BBA patients.

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