Статья

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Andrew RhodesSt. George’s Hospital London, England, United KingdomLaura EvansNew York University School of Medicine New York, NYWaleed AlhazzaniMcMaster University Hamilton, Ontario, CanadaMitchell M. LevyBrown University School of Medicine Providence, RIMassimo AntonelliInstituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore, Rome, ItalyRicard FerrerVall d’Hebron University Hospital Barcelona, SpainAnand KumarUniversity of Manitoba Winnipeg, Manitoba, CanadaJonathan SevranskyEmory University Hospital Atlanta, GACharles L. SprungHadassah Hebrew University Medical Center Jerusalem, IsraelMark NunnallyNew York University School of Medicine New York, NYBram RochwergMcMaster University Hamilton, Ontario, CanadaGordon D. RubenfeldSunnybrook Health Sciences Centre Toronto, Ontario, CanadaDerek C. AngusUniversity of Pittsburgh Critical Care Medicine CRISMA Laboratory Pittsburgh, PADjillali AnnaneHospital Raymond Poincare Garches, FranceRichard BealeSaint Thomas Hospital London, England, United KingdomGeoffrey J. BellinghanUniversity College London Hospitals London, England, United KingdomGordon R. BernardVanderbilt University Medical Center Nashville, TNJean‐Daniel ChicheService de Reanimation Medicale Paris, FranceCraig CoopersmithEmory University Hospital Atlanta, GADaniel De BackerCHIREC Hospitals Braine L’Alleud, BelgiumCraig FrenchWestern Hospital Victoria, AustraliaSeitaro FujishimaKeio University School of Medicine, Tokyo, JapanHerwig GerlachVivantes-Klinikum Neukölln, Berlin, GermanyJorge HidalgoKarl Heusner Memorial Hospital Belize Healthcare Partners Belize City, BelizeSteven M. HollenbergCooper Health System Camden, NJAlan E. JonesUniversity of Mississippi Medical Center Jackson, MSDilip R. KarnadJupiter Hospital Thane, IndiaRuth KleinpellRush University Medical Center Chicago, ILYounsuck KohASAN Medical Center University of Ulsan College of Medicine Seoul, South KoreaThiago LisboaHospital de Clinicas de Porto Alegre Porto Alegre, BrazilFlávia Ribeiro MachadoFederal University of Sao Paulo Sao Paulo, BrazilJohn J. MariniRegions Hospital St. Paul, MNJohn C. MarshallSaint Michael’s Hospital Toronto, Ontario, CanadaJohn E. MazuskiWashington University School of Medicine St. Louis, MOLauralyn McIntyreOttawa Hospital Ottawa, Ontario, CanadaAnthony S. McLeanNepean Hospital, University of Sydney Penrith, New South Wales, AustraliaSangeeta MehtaMount Sinai Hospital Toronto, Ontario, CanadaRui P. MorenoUCINC, Centro Hospitalar de Lisboa Central, Lisbon, PortugalJohn MyburghUniversity of New South Wales, Sydney, New South Wales, AustraliaPaolo NavalesiUniversità dellla Magna Graecia Catanzaro, ItalyOsamu NishidaFujita Health University School of Medicine, Toyoake, Aich, JapanTiffany M. OsbornWashington University School of Medicine St. Louis, MOAnders PernerRigshospitalet Copenhagen, DenmarkColleen M. PlunkettRush University Medical Center Chicago, ILMarco RanieriUniversità Sapienza, Rome, ItalyChrista SchorrCooper Health System Camden, NJMaureen A. SeckelChristiana Care Health Services Newark, DEChristopher W. SeymourUniversity of Pittsburgh School of Medicine Pittsburgh, PALisa ShiehStanford University School of Medicine Stanford, CAKhalid ShukriKaust Medical Services Thuwal, Saudi ArabiaSteven Q. SimpsonUniversity of Kansas Medical Center Kansas City, KSMervyn SingerWolfson Institute of Biomedical Research London, England, United KingdomBruce ThompsonMassachusetts General Hospital Boston, MASean R. TownsendCalifornia Pacific Medical Center San Francisco, CAT. van der PollUniversity of Amsterdam Amsterdam, NetherlandsJean‐Louis VincentErasmé University Hospital Brussels, BelgiumW. Joost WiersingaUniversity of Amsterdam, Amsterdam, NetherlandsJanice L. ZimmermanHouston Methodist Hospital, Houston, TXR. Phillip DellingerCooper Health System Camden, NJ

2017en

ABI

Аннотация

OBJECTIVE: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012." DESIGN: A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development. METHODS: The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable. RESULTS: The Surviving Sepsis Guideline panel provided 93 statements on early management and resuscitation of patients with sepsis or septic shock. Overall, 32 were strong recommendations, 39 were weak recommendations, and 18 were best-practice statements. No recommendation was provided for four questions. CONCLUSIONS: Substantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.

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Идентификаторы

DOI: 10.1097/ccm.0000000000002255

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Цитирований: 4Использованных источников: 0

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