Chemical N-Glycosylation byAsparagine under Integrated Microfluidic/Batch Conditions

An integrated microfluidic/batch system was applied to the chemical N-glycosylation by the asparagine amide group, a key glycosyl bond-formation reaction in the synthesis of N-glycopeptides. By applying the advantageous features of microfluidic conditions, that is, efficient mixing and rapid heat transfer, the GlcNTrocβAsn and the Fucα(1-6)GlcNTrocβAsn fragments were efficiently prepared.

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