2-Naphthylmethoxymethyl as a Mildly Introducible and Oxidatively Removable Benzyloxymethyl-Type Protecting Group
Takuya SatoDepartment of Chemistry,
Faculty and Graduate School of Sciences, Kyushu University, 6-10-1
Hakozaki, Higashi-ku, Fukuoka 812-8581, JapanTohru OishiDepartment of Chemistry,
Faculty and Graduate School of Sciences, Kyushu University, 6-10-1
Hakozaki, Higashi-ku, Fukuoka 812-8581, JapanKohei TorikaiDepartment of Chemistry,
Faculty and Graduate School of Sciences, Kyushu University, 6-10-1
Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
2015en
ABI
Аннотация
2-Naphthylmethoxymethyl (NAPOM) was developed for the protection of various hydroxy (including phenolic hydroxy and carboxy) and mercapto groups. The NAPOM group can be introduced in extremely mild conditions (naphthylmethoxymethyl chloride, 2,6-lutidine, room temperature) without concomitant acyl migration in a 1,2-diol system. Furthermore, selective removal of NAPOM in the presence of naphthylmethyl (NAP) and p-methoxybenzyl (PMB) groups and, conversely, that of PMB in the presence of NAPOM were realized. These results, as well as its easy handling and compatibility with various solvents, show that NAPOM is a novel and useful choice as a protecting group.
Перевод пока недоступен
Идентификаторы
Цитирования и источники
Цитирований: 2Использованных источников: 0