Practical Synthesis of a Manβ(1-4)GlcNTroc Fragment via Microfluidic β-Mannosylation
Katsunori TanakaDepartment of Chemistry, Graduate School of Science , Osaka University , Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, JapanYasutaka MoriDepartment of Chemistry, Graduate School of Science , Osaka University , Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, JapanKoichi FukaseDepartment of Chemistry, Graduate School of Science , Osaka University , Machikaneyama 1-1, Toyonaka, Osaka, 560-0043, Japan
2009en
ABI
Аннотация
Combined microfluidic/batch conditions were applied to β-mannosylation, a key glycosylation for the synthesis of the Manβ(1-4)GlcNAc motif in N-glycan structures. By applying the advantageous features of microfluidic conditions (i.e., efficient mixing and fast heat transfer), the Manβ(1-4)GlcNTroc fragment was practically and reproducibly synthesized on the gram scale.
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