Optimization of Glycosylation Reactions in a Microreactor
Karolin GeyerLaboratory of Organic Chemistry, Swiss Federal Institute of Technology (ETH), Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, (fax: (+41) 44 633 1235)Peter H. SeebergerLaboratory of Organic Chemistry, Swiss Federal Institute of Technology (ETH), Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, (fax: (+41) 44 633 1235)
2007en
ABI
Аннотация
Abstract Glycosylations are notoriously difficult reactions that require extensive optimization regarding the type of anomeric leaving group, solvent, reaction temperature, and reaction time. Described is the use of a silicon‐based microreactor to screen reaction conditions and to scale‐up synthetic procedures. For the first time, glycosyl phosphates were employed in a microreactor. The optimized reaction conditions were successfully transferred to a batch process.
Перевод пока недоступен
Идентификаторы
Цитирования и источники
Цитирований: 2Использованных источников: 0